DIAGNOSTIC TECHNIQUE FOR PULMONARY TUBERCULOSIS Russian patent published in 2013 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: patient's whole blood is incubated with mycobacterial antigens representing a mixture of the proteins ESAT-6, CFP-10, TB 7.7, centrifuged to separate plasma; the supernatant is examined for the content of antigen-induced gamma-interferon (IFNγ), antigen-induced interleukin-6 (IL-6) and spontaneous production of transforming growth factor-α (TGFα). If observing IFNγ ≥6.4 IU/ml, or IL-6≥2039 pg/ml, or TGFα≥17.0 pg/ml, the active tuberculosis infection is stated. All three values being below the threshold show the latent infection.

EFFECT: using the given technique enables the differential diagnostic between the individuals suffering active tuberculosis and latent tuberculosis infection.

6 ex, 1 dwg, 1 tbl