NEW DERIVATIVES OF PEG Russian patent published in 2019 - IPC C08G65/333 A61K47/50 A61K47/60 A61K31/337 A61K31/407 A61K31/496 A61K31/513 A61K31/7068 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention refers to a compound of formula (1) or its pharmaceutically acceptable salt

,

where R¹ is a single bond, -N(R³)(CH₂)_n1CO- or -N(R⁴)(CH₂)_n2N (R⁵)CO(CH₂)_n3CO- (where R³ is a hydrogen atom or an alkyl group having 1–6 carbon atoms; R⁴ and R⁵ are bonded together and represent an alkylene group having 1–4 carbon atoms; and n1, n2 and n3 are identical or different from each other, each being integer from 1 to 3); R² is (2'-cyano-2'-deoxy-β-D-arabinofuranosyl) cytosine or a group of formulas (b), (d), (e) or (f)

, ,

(e), (f ),

where R¹⁵ is an alkyl group having 1–6 carbon atoms; and R¹⁶ represents a hydrogen atom or an alkanoyl group having 2–6 carbon atoms; m is equal to number from 10 to 1000; and arrow denotes binding point. Also disclosed are embodiments of using said compound, a drug and a pharmaceutical composition for treating a malignant tumour containing it, and a method of treating a malignant tumour with using it.

EFFECT: technical result is development of new therapeutic agent for malignant tumour, which is very safe, enables to reduce negative side effects, such as severe gastrointestinal toxicity or bone toxicity, has a stable anti-tumour effect and enables improving administration and administration frequency.

8 cl, 16 dwg, 7 tbl, 10 ex