NOVEL DIMERS OF CYTIDINE DERIVATIVES AND USE THEREOF Russian patent published in 2019 - IPC C07H19/73 A61P35/02 C07H1/00 A61P35/04 A61K31/7068 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a dimer of a cytidine derivative of formula (I), use thereof for producing an antitumour agent, pharmaceutical compositions based thereon and a method for production thereof, which can be used in medicine and pharmaceutical industry

(I),

where R1 and R2 independently represent C₄-alkyl or -(CH₂)-Ph; R3 is hydrogen or C₄-alkoxycarbonyl; R4 is hydrogen or C₄-alkoxycarbonyl; R5 is -(CH₂)_2-3-. Method involves preparing compounds of formulas (II) and (III), converting a compound of formula (II) into a compound of formula (IV) and reacting compounds (IV) and (III) to obtain a dimer of formula (I)

(II) (III)

(IV)

EFFECT: novel compounds effective for treating malignant solid tumours, pharmaceutical compositions based thereon and an effective method for preparing them are disclosed.

8 cl, 4 ex, 9 tbl, 6 dwg