FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a method for preparing a combined preparation and the combined preparation itself for treating, preventing, or relieving gastrointestinal disorders, or alleviating gastrointestinal symptoms, comprising: a first composition which contains mosapride or a pharmaceutically acceptable salt thereof as a first active ingredient, and a second composition which contains rabeprazole or a pharmaceutically acceptable salt thereof as a second active ingredient, wherein the combined preparation has a tablet structure with a core in which the second composition is contained as an inner core and the first composition surrounds the outer layer of the second composition.
EFFECT: group of inventions provides fast release of a drug from the preparation without disturbing its release by interaction between mosapride and rabeprazole, thus demonstrating an improved degree of drug release and bioavailability, wherein the preparation has excellent stability.
4 cl, 5 dwg, 9 tbl, 9 ex
Title | Year | Author | Number |
---|---|---|---|
COMBINED PHARMACEUTICAL WITH TABLET IN CORE, CONTAINING MOSAPRIDE AND RABEPRAZOLE | 2018 |
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Authors
Dates
2019-08-21—Published
2016-06-27—Filed