COMBINED PREPARATION OF MOSAPRIDE AND RABEPRAZOLE Russian patent published in 2019 - IPC A61K9/20 A61K9/48 A61K31/535 A61K31/416 A61K47/00 A61P1/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a method for preparing a combined preparation and the combined preparation itself for treating, preventing, or relieving gastrointestinal disorders, or alleviating gastrointestinal symptoms, comprising: a first composition which contains mosapride or a pharmaceutically acceptable salt thereof as a first active ingredient, and a second composition which contains rabeprazole or a pharmaceutically acceptable salt thereof as a second active ingredient, wherein the combined preparation has a tablet structure with a core in which the second composition is contained as an inner core and the first composition surrounds the outer layer of the second composition.

EFFECT: group of inventions provides fast release of a drug from the preparation without disturbing its release by interaction between mosapride and rabeprazole, thus demonstrating an improved degree of drug release and bioavailability, wherein the preparation has excellent stability.

4 cl, 5 dwg, 9 tbl, 9 ex