DNA-DEPENDENT PROTEIN KINASE INHIBITOR Russian patent published in 2025 - IPC C07D519/00 C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula (I), pharmaceutically acceptable salts thereof, individual compounds presented in the claim, a pharmaceutical composition, a method of inhibiting DNA-PK and a method of treating a disorder associated with DNA-PK. In formula I X₁, X₂ and X₃ each independently is C, CH or N, provided that at least one of X₁, X₂ and X₃ is N, and at least one of X₁, X₂ and X₃ is C; dotted line means that the bond between X₁ and X₂ and between X₂ and X₃ can be a single or double bond, provided that at least one of the bonds between X₁ and X₂ and between X₂ and X₃ is a simple bond; R¹ is absent or is C_1-6alkyl, where said C_1-6alkyl can be optionally substituted with 1 to 3 halogen or deuterium; each R² and R⁴ is absent or is independently selected from halogen, C_1-6alkyl, C_1-6alkoxyl, -(CH₂)_n-Q, which can be independently substituted with 1 to 3 deuterium, hydroxyl, cyano, halogen, C_1-6alkyl, C_1-6haloalkyl, C_1-6alkoxyl, C_1-6haloalkoxyl, C_3-8cycloalkyl or C_3-8cycloalkoxyl, or R² is selected from

which can be independently substituted with 1 to 3 hydroxyl, cyano, fluorine, chlorine, bromine, methyl, ethyl, methoxyl, difluoromethyl, difluoromethoxyl or trifluoromethoxyl; R³ is selected from halogen, C_1-6alkyl, C_1-6alkoxyl, which can be independently substituted with 1 to 3 deuterium, hydroxyl, cyano, halogen, C_1-6alkyl, C_1-6haloalkyl, C_1-6alkoxyl or C_1-6haloalkoxyl, where n is equal to 0, 1 or 2, Q is 3-8-membered saturated or unsaturated carbocyclyl or 3-8-membered saturated or unsaturated heterocyclyl having 1 or 2 ring heteroatoms independently selected from oxygen and nitrogen, where one ring-forming group -CH₂- heterocyclyl can be substituted with -C(O)-; ring A is 6-member heteroaryl having 1 ring heteroatom of nitrogen, or 9-member bicyclic ring having 2-3 ring heteroatoms selected from oxygen, sulphur and nitrogen.

EFFECT: compound of formula (I) as a DNA-dependent protein kinase (DNA-PK) inhibitor.

26 cl, 7 tbl, 120 ex