FIELD: chemistry.
SUBSTANCE: invention relates to salts of (5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)methanesulphonic acid of general formula I:
and a method for production thereof. Disclosed method of producing (5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)methanesulphonic acid differs from known analogues in fewer steps, higher output, use of cheaper and less toxic reagents and solvents, less amount of wastes and lower toxicity thereof. Disclosed purification method enables to obtain highly pure (5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)methanesulphonic acid with impurity content of less than 0.1 %.
EFFECT: claimed salts I-2 – I-13 are synthesized from (5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridin-2-yl)methanesulphonic acid in one step by simple neutralization reaction and have significantly better solubility in water as compared to with initial acid.
2 cl, 4 dwg, 57 ex
где - where
| Title | Year | Author | Number |
|---|---|---|---|
| PYRIDOXINE-BASED COMPOUNDS CAPABLE OF GLUCOKINASE ENZYME ACTIVATION | 2017 |
|
RU2644355C1 |
| DERIVATIVE PYRIDOXIN FOR TREATMENT OF EPILEPSY | 2017 |
|
RU2650523C1 |
| NON-STEROID ANTI-INFLAMMATORY AGENTS BASED ON PYRIDOXINE DERIVATIVES | 2012 |
|
RU2513089C1 |
| PHOSPHONIUM SALTS ON BASIS OF PYRIDOXINE DERIVATIVES | 2011 |
|
RU2466728C1 |
| PYRIDOXINE DERIVATIVE-BASED BETA-ADRENERGIC BLOCKING AGENTS | 2014 |
|
RU2569900C1 |
| PYRIDOXINE DERIVATIVES WITH NONLINEAR OPTICAL PROPERTIES | 2012 |
|
RU2501801C1 |
| ANTIBACTERIAL COMPOUNDS BASED ON SULPHANILIC ACID AND PYRIDOXINE | 2012 |
|
RU2480471C1 |
| QUATERNARY AMMONIUM COMPOUNDS BASED ON PENTAERYTHRITOL AND PYRIDOXINE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | 2023 |
|
RU2811203C1 |
| INHIBITORS OF FORMATION OF GLYCATION END PRODUCTS BASED ON AZO-DERIVATIVE PHENYLSULPHONIC ACIDS | 2016 |
|
RU2634594C1 |
| ANTIBACTERIAL AGENTS BASED ON QUATERNARY AMMONIUM SALTS | 2014 |
|
RU2561281C1 |
