FIELD: chemistry.
SUBSTANCE: invention relates to synthetic biologically active substances of the heterocyclic series, having high antiadrenergic activity, which are beta-substituted alcohols containing a pyridoxine fragment of general formula 1: 
, where: 1a R1+R2=-C(CH3)2-, R3=NHCH(CH3)2; 1b R1+R2=-C(CH3)2-, R3=NHC(CH3)3;1c R1+R2=-C(CH3)2-, R3=NHC12H25; 1d R1+R2=-C(CH3)2-, R3=NHC(CH3)2 CH2CH3; 1e R1+R2=-C(CH3)2-, R3=N(CH2CH2)2 O; 1f R1+R2=-C(CH3)2-, R3=N(CH2CH2)2 CH2; 1g R1+R2=-C(CH3)2-, R3=OCH(CH3)2; 1h R1+R2=-C(CH3)2-, R3=OCH2CH3; 1i R1=H, R2=H, R3=OH;1j R1+R2=-CH(CH3)-, R3=NHCH(CH3)2; 1k R1+R2=-CH(CH3)-, R3=NHC(CH3)3; 1l R1+R2=-CH(CH3)-, R3=NHC(CH3)2CH2CH3; 1m R1+R2=-CH(CH3)-, R3=N(CH2CH2)2O; 1n R1+R2=-CH(CH3)-, R3=N(CH2CH2)2CH2; 1o R1+R2=-CH(CH3)-, R3=OCH2CH3.
EFFECT: compounds of general formula 1 have high efficiency and duration of antiadrenergic properties with a short time for the onset of the effect and low toxicity.
2 dwg, 20 ex
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