PYRIDOXINE DERIVATIVE-BASED BETA-ADRENERGIC BLOCKING AGENTS Russian patent published in 2015 - IPC C07D213/28 C07D491/56 A61K31/44 A61P9/00 

Abstract RU 2569900 C1

FIELD: chemistry.

SUBSTANCE: invention relates to synthetic biologically active substances of the heterocyclic series, having high antiadrenergic activity, which are beta-substituted alcohols containing a pyridoxine fragment of general formula 1: , where: 1a R1+R2=-C(CH3)2-, R3=NHCH(CH3)2; 1b R1+R2=-C(CH3)2-, R3=NHC(CH3)3;1c R1+R2=-C(CH3)2-, R3=NHC12H25; 1d R1+R2=-C(CH3)2-, R3=NHC(CH3)2 CH2CH3; 1e R1+R2=-C(CH3)2-, R3=N(CH2CH2)2 O; 1f R1+R2=-C(CH3)2-, R3=N(CH2CH2)2 CH2; 1g R1+R2=-C(CH3)2-, R3=OCH(CH3)2; 1h R1+R2=-C(CH3)2-, R3=OCH2CH3; 1i R1=H, R2=H, R3=OH;1j R1+R2=-CH(CH3)-, R3=NHCH(CH3)2; 1k R1+R2=-CH(CH3)-, R3=NHC(CH3)3; 1l R1+R2=-CH(CH3)-, R3=NHC(CH3)2CH2CH3; 1m R1+R2=-CH(CH3)-, R3=N(CH2CH2)2O; 1n R1+R2=-CH(CH3)-, R3=N(CH2CH2)2CH2; 1o R1+R2=-CH(CH3)-, R3=OCH2CH3.

EFFECT: compounds of general formula 1 have high efficiency and duration of antiadrenergic properties with a short time for the onset of the effect and low toxicity.

2 dwg, 20 ex

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RU 2 569 900 C1

Authors

Shtyrlin Jurij Grigor'Evich

Pavel'Ev Roman Sergeevich

Khajrullina Regina Rishatovna

Ziganshina Lilija Evgen'Evna

Aleksandrova Ehl'Vira Grigor'Evna

Safina Alija Faritovna

Iksanova Al'Fija Gabdulakhatovna

Sitdikova Guzel' Faritovna

Khaertdinov Nil' Nazimovich

Dates

2015-12-10Published

2014-11-24Filed