FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to clinical-laboratory diagnostics, and can be used for prediction of placental insufficiency development. That is ensured by extracting extracellular DNA from pregnant blood plasma with subsequent determination of the fetal genotype by rs4065 of the PLAU gene. If observing the CC genotype in a fetus, the pregnant woman is referred to a risk group of placental insufficiency. What is also presented is application of a test system containing primers and probes specific to rs4065 polymorphism of PLAU gene.
EFFECT: group of inventions enables predicting the development of placental insufficiency with a high degree of reliability in early pregnancy by determining the genotype of the fetus according to urokinase gene polymorphism with its fastness and safety.
4 cl, 12 dwg, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR NON-INVASIVE PRENATAL DIAGNOSTICS OF TRISOMY AND A SET FOR IT | 2020 |
|
RU2734484C1 |
| METHOD FOR ASSESSMENT OF CONTRIBUTION OF FETAL THROMBOPHILIA IN FORMATION OF SUB- AND DECOMPENSATED FORMS OF PLACENTAL INSUFFICIENCY | 2017 |
|
RU2677466C1 |
| APPLICATION OF DNA-DIAGNOSTICS FOR PRESENCE OF POLYMORPHISM R353Q IN GENE OF FACTOR VII OF BLOOD COAGULATION FOR ESTIMATION OF PREDISPOSITION TO DEVELOPMENT OF HABITUAL NONCARRYING OF PREGNANCY AND METHOD OF PREDISPOSITION ESTIMATION TO THIS DISEASE BY MEANS OF ANALYSIS OF COMBINATION OF POLYMORPHISMS C677T OF GENE MTHFR AND OF GENE R353Q OF FACTOR VII | 2006 |
|
RU2330071C1 |
| METHOD FOR DETECTING GENETIC PREDISPOSITION TO RECURRENT PREGNANCY LOSS | 2012 |
|
RU2532367C2 |
| METHOD FOR GENETIC MARKER PREDICTION OF RISK OF GESTOSIS | 2010 |
|
RU2431842C1 |
| METHOD FOR PREDICTING NEWBORN WEIGHT IN PREGNANT WOMEN WITH PREECLAMPSIA IN COMBINATION WITH FETAL GROWTH RETARDATION SYNDROME | 2020 |
|
RU2741861C1 |
| METHOD FOR PREDICTING CONGENITAL CLEFT LIP AND PALATE IN A CHILD WHEN PLANNING PREGNANCY IN A REGION WITH ECOTOXICANTS USING GENETIC MARKERS | 2021 |
|
RU2760786C1 |
| NONINVASIVE DIAGNOSTIC DNA TEST FOR ANEUPLOIDY DETECTION | 2012 |
|
RU2638456C2 |
| METHOD FOR EARLY PREDICTION OF CHORION AND PLACENTA DETACHMENT ON BASIS OF DETECTING GENE POLYMORPHISM OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | 2012 |
|
RU2494400C1 |
| METHOD FOR PREDICTING RISK OF FORMING SUB- AND DECOMPENSATED PLACENTAL INSUFFICIENCY WITH OUTCOME IN SYNDROME OF FETAL GROWTH RETARDATION ON BASIS OF GENETIC PECULIARITIES OF ENERGY EXCHANGE OF MATERIALS | 2017 |
|
RU2677335C1 |
