FIELD: medicine.
SUBSTANCE: invention aims at detecting the genetic predisposition to the recurrent pregnancy loss (RPL). Genome DNA is recovered from a blood sample of a person being tested. Polymorphous variants of 34V/L FXIII gene, M235T AGT gene, 4a/b eNOS gene, PLA1/A2 GpIIIa gene and 353R/Q FVII gene are genotyped. After completing the genotyping procedure covering all 5 genes, the action of the recovered alleles is stated to develop the predisposition to RPL by calculating a composite score, and the derived data are used to draft a final statement. The total score of <0.16 provides a basis to refer the person being tested to a low-risk group; the total score falling within the range of 0.16 to 0.40 points provides referring the patient to a moderate-risk group, and the value being >0.40 points shows the high-risk of developing RPL.
EFFECT: method enables finding female groups of a low, moderate or high risk of RPL that is needed for the timely pre-pregnancy prevention or correction of the detected disorders.
5 dwg, 9 tbl, 7 ex
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