METHOD FOR PREDICTING RISK OF FORMING SUB- AND DECOMPENSATED PLACENTAL INSUFFICIENCY WITH OUTCOME IN SYNDROME OF FETAL GROWTH RETARDATION ON BASIS OF GENETIC PECULIARITIES OF ENERGY EXCHANGE OF MATERIALS Russian patent published in 2019 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to obstetrics and gynecology, and relates to a method for predicting the risk of the formation of sub-and decompensated placental insufficiency with the outcome of fetal growth retardation. Essence of the method: perform the determination of the most informative combinations of pathological polymorphisms of energy metabolism genes PPARD(-87C>T), PPARGC 1A(S482G G>A) and AMPD(Q12X G>A), and a study of low-density lipoprotein (LDL) and maternal cholesterol. Then calculate the prognostic index D by the formula: D=0.19*X1+0.39*X2-0.71*X3-1.04*X4-0.68*X5-1.86, where D is the prognostic index, X1 is the cholesterol level in mmol/l in the woman’s blood, X2 is the low density lipoprotein (LDL) level in mmol/l in the woman’s blood, X3 is the woman’s genotypes containing the PPARD(-87C>T) polymorphic DNA locus variant allele 87_T in the homozygous and heterozygous state: if there is – 1, if not – 0, X4 – the presence of genotypes in a woman containing the S482 A variant allele of the PPARGC 1 A(S482G G>A) polymorphic DNA locus in the homo- and heterozygous state: if there is -1, if not – 0, X5 – the presence of genotypes in a woman containing the Q12X_A variant allele of AMPD(Q12X G>A) polymorphic DNA locus in the homo- and heterozygous state: if there is – 1, if not – 0, – 1.86 – CONST. Risk of sub-and decompensated placental insufficiency with an outcome in growth retardation syndrome, is estimated depending on the value of the indicator D: D<0 corresponds to a high risk, D≥0 – low.

EFFECT: method allows, with a high degree of probability, to predict the formation of sub- and decompensated placental insufficiency with an outcome in Fetal Growth Retardation Syndrome and to allocate women at high risk to form this pathology.

1 cl, 2 ex