METHOD FOR DEVELOPING BIOMARKERS OF DISEASES AND PHYSIOLOGICALLY ACTIVE SUBSTANCES BASED ON EXTENDED VERSION OF THE IPANDA ALGORITHM Russian patent published in 2019 - IPC G01N33/48 C12Q1/68 G06F3/06 G06F12/02 

FIELD: medicine.

SUBSTANCE: proposed group of inventions relates to medicine. Method and a system for evaluating the efficacy of drug candidates selected from a group of drug candidates for a physiological process are disclosed. Method involves obtaining data from samples in which said physiological process takes place, and from control samples in which said physiological process does not occur, determining a set of genes or their products and signalling pathways statistically significantly activated or inhibited in samples in which said physiological process, as compared to control samples, determining a set of genes and signalling pathways after exposure of each drug candidate selected from a group of drug candidates to cells or biological tissues in which said physiological process can occur, and determining efficacy values for said physiological process for each drug candidate.

EFFECT: proposed group of inventions provides a more effective method of assessing the effectiveness of drug candidates for a physiological process.

3 cl, 7 dwg, 3 tbl, 3 ex