MOLECULAR STRUCTURES WITH TARGETING AND EFFECTOR ELEMENTS AND METHODS FOR USE THEREOF Russian patent published in 2019 - IPC A61K39/395 C07K16/46 C12P21/08 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology. Described is a group of inventions comprising a linker comprising a central core, connecting branches and, optionally, a connecting branch (embodiments). In one embodiment, the linker comprises a central core which contains a first polypeptide containing lysine (K) residues, where each and subsequent residue K are separated by an intervening sequence containing glycine and serine residues, and the polypeptide has length of 8 to 120 amino acid residues and the number of residues K ranges from 2 to 15; or second polypeptide containing sequence (X_aa-K)_n, where each X_aa is a pegylated amino acid having from 2 to 12 repeating ethylene glycol links, and n is integer from 2 to 15; binding branches are connected to residues K of the central core, where each of the binding branches is a PEG chain having 2 to 20 repeating EG-links.

EFFECT: invention extends the range of linker links.

16 cl, 81 dwg, 39 ex