CARBOXAMIDE DERIVATIVES OF ISOXAZOLINE, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATING INFLAMMATORY DISEASES Russian patent published in 2019 - IPC C07D413/04 C07D413/14 A61K31/422 A61P19/02 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to carboxamide derivatives of an isoxazoline series of general formula 1, having properties which enable to deactivate receptors PAR-2 (receptors activated by proteases), as well as to a method for decontaminating the PAR-2 receptor, as well as to an active component of formula 1, having anti-inflammatory action. In general formula 1, X represents nitrogen atom, or C-H, or C-Cl; R₁ substitute is 2,6-dimethylphenyl, 4-methyl-2-chlorophenyl, mesityl, 4-methoxy-3-trifluoromethylphenyl, 3,4-dimethylphenyl, 2-methyl-6-chlorophenyl, 2-trifluoromethyl-4-chlorophenyl, 4-trifluoromethoxyphenyl, 3,4-dicyanophenyl, 4-chlorpyridin-2-yl, 4-isopropoxy-3-cyanophenyl, 3-chloro-4-cyanophenyl, 4-(trifluoromethylphenyl); R₂ substitute, R₃ can be selected from the following set - hydrogen, C₁-C₆ alkyl.

EFFECT: compounds can be used for treating inflammatory diseases, particularly rheumatoid arthritis, as well as other diseases, the treatment of which can be associated with deactivation of PAR2 receptors.

4 cl, 1 tbl, 6 ex