THIENOPYRIDONE CARBOXAMIDES AND THEIR MEDICAL USE Russian patent published in 2009 - IPC C07D495/04 A61K31/4365 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I)

, where R is selected from ethyl, n-propyl, iso-propyl, n-butyl and allyl; R' is selected from hydrogen, straight, branched or cyclic C₁-C₄alkyl; straight, branched or cyclic C₁-C₃alkoxy; fluorine, chlorine, bromine, trifluoromethyl and OCH_xF_y, where x=0, 1, 2, y=1, 2, 3 under the condition that, x+y=3; R" is selected from hydrogen, fluorine and chlorine, with the condition that, R" is selected from fluorine and chlorine only when R' is selected from fluorine and chlorine; R₃ is selected from hydrogen and straight, branched or cyclic C₁-C₅alkyl; R₄ is selected from hydrogen, CH₂OCOC(CH₃)₃, pharmaceutically acceptable inorganic or organic cations, and COR₄', where R' is straight, branched or cyclic C₁-C₅alkyl, phenyl, benzyl or phenethyl; R₇ is selected from methyl and ethyl; one of A and B is sulphur, and the other is C-R₂; when A is S, R₂ is selected from hydrogen and methyl, with the condition that R₂ is methyl only when R₃ is not hydrogen; and when B is S, R₂ is hydrogen; and to any tautomer thereof, as well as to a pharmaceutical composition which contains formula (I) compound, to a method of producing said compounds and to a method of treating diseases which are a result of autoimmune response or pathologic inflammation.

EFFECT: new compounds are disclosed, which can be used in treating diseases which are a result of autoimmune response or pathologic inflammation.

35 cl, 2 tbl, 18 ex