METHODS AND COMPOSITIONS FOR TREATING DISORDERS OF OESOPHAGUS Russian patent published in 2019 - IPC A61K31/131 A61K31/132 A61K47/32 A61K47/04 A61K9/22 A61P1/04 A61K31/4439 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and pharmacy. Disclosed is a pharmaceutical composition for oral administration for treating or preventing a disorder of the upper gastrointestinal tract, selected from dyspepsia, epigastric burning, erosive oesophagitis, gastroesophageal reflux disease, peptic ulcer, oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma containing a therapeutically effective amount of at least one bile acid sequestrant selected from one or more substances from colesevelam, colesevelam hydrochloride, sevelamer and combinations thereof, and a gastric retention carrier composition containing one or more hydrogels, wherein the composition expands upon contact with gastric juice. Also disclosed is a sustained release pharmaceutical dosage form containing the above composition and a method for prevention or treatment of an upper gastrointestinal disorder comprising administering a therapeutically effective amount of the declared composition or pharmaceutical dosage form.

EFFECT: technical result consists in the implementation of the declared application, wherein releasing the colesevelam from the composition takes place in the stomach for more than 9 hours.

13 cl, 2 ex