IBAT INHIBITOR FOR TREATING HEPATIC DISORDERS Russian patent published in 2016 - IPC C07D285/36 C07D281/10 A61K31/554 A61P1/16 

FIELD: chemistry.

SUBSTANCE: present invention relates to use of compounds of formula II for treating and/or preventing liver disease mediated IBAT selected from Alajil syndrome (ALGS), progressive family inside liver cholestasis (PFIC), primary billiar cirrhosis (PBC), primary sclerosing cholangitis (PSC), non-alcoholic liver steatohepatitis (NASH) and itching caused by cholestatic liver disease, as well as to based pharmaceutical composition and method of treating said diseases. In general formula II M denotes CH₂ or NH; R¹ denotes H or hydroxy; R² represents H, CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH₂CH₂CH₂CH₃, -CH(CH₃)₂, -CH₂CH(CH₃)₂, -CH(CH₃)CH₂CH₃, -CH₂OH, -CH₂OCH₃, -CH(OH)CH₃, -CH₂SCH₃ or -CH₂CH₂SCH₃.

EFFECT: treating and preventing hepatic disorders.

11 cl, 1 tbl, 20 ex