FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented prolonged release pharmaceutical oral dosage form for preventing or treating an upper gastrointestinal disorder (dyspepsia, epigastric burning, erosive esophagitis, gastrooesophageal reflux disease, peptic ulcer, esophagitis, Barrett's esophagus and esophageal adenocarcinoma), containing a therapeutically effective amount of at least one bile acid sequestrant specified in colesevelam and colesevelam hydrochloride, and a carrier composition providing gastric retention containing one or more hydrogels, wherein the dosage form expands upon contact with gastric juice, respective methods of treating or preventing the upper gastrointestinal disorder and protecting the multilayer squamous epithelium against an attack of any hazardous substances by administering the composition, and a kit for the same application comprising the composition, a label or a package insert with instructions for use. The composition may contains a proton pump inhibitor, and one or more agents specified in antacids, histamine H2-receptor antagonists, γ-aminobutyric acid-b (GABA-B) agonists, and protease inhibitors.
EFFECT: invention aims at retaining the active agent in the stomach for relieving and improving prolonged delivery thereof.
16 cl, 2 ex
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