FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a pharmaceutical composition for preventing and/or treating prostate cancer comprising a therapeutically effective amount of one selected from a group consisting of a benzoheterocyclic compound, presented by formula (I), its pharmaceutically acceptable salt, its stereoisomer, its deuterated compound or its racemate, and a modulator of the androgen receptor signaling pathway. In formula (I), n1 equals 0 or 1; L1 and L3 are independently 
, CH2 or 
; L2 is CH2; X is NH or O; R1, R2 and R3 are independently H; Z is 
; where R4 is H or D; R5, R6, R7, R8 and R9 are H; carbon atom denoted by * represents a center of asymmetry; R10 is H or 
; where R1', R2', R3', R4' and R5' are independently selected from H or substituted (C1-C4) alkyl; substitute with substituted (C1-C4) alkyl is morpholinyl; if n1 equals 0, X denotes NH, L1 is , CH2; and L3 is in formula (I), R10 is H; if n1 equals 0, X denotes NH, L1 is, and L3 is in formula (I), R10 is H; if n1 equals 1, L1 is CH2, L3 is in formula (I), R10 is ; D is a deuterium-enriched hydrogen atom and H is a deuterium-poor hydrogen atom; modulator of the androgen receptor signaling pathway is selected from a group consisting of enzalutamide, ARN-509, galterone, ODM-201, abiberone acetate, enzalutamide and gaitherone, enzalutamide and abiraterone acetate, ARN-509 and gaitherone and ARN-509 and abiraterone acetate. Invention also relates to use of a benzoheterocyclic compound represented by formula (I), in preparing a medicinal preparation, to methods for preventing and/or treating prostate cancer.
EFFECT: technical result: novel pharmaceutical compositions for preventing and/or treating prostate cancer.
17 cl, 11 tbl
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