FIELD: chemistry.
SUBSTANCE: invention refers to analytical chemistry and consists in creation of piezoelectric sensor for determination of drug substances of fluoroquinolone series – levofloxacin and ciprofloxacin. For this purpose, the surface of the sensor is coated with a substrate based on a self-assembled monolayer of 2-amino-3-mercaptopropanoic acid (cysteine), on which activated carbon nanotubes (CNT) are fixed and a fluoroquinolone-protein conjugate is immobilized.
EFFECT: invention widens the range of detectable content when analyzing fluoroquinolones in liquid media, and also provides multiple use of immunosensor after regeneration of the bioreceptor coating, which reduces the cost of analysis.
1 cl, 1 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PIEZOELECTRIC SENSOR COATING BASED ON MAGNETIC CARBON NANOCOMPOSITES | 2022 |
|
RU2783225C1 |
| METHOD OF DETERMINING TETRACYCLINES USING A PIEZOELECTRIC SENSOR | 2017 |
|
RU2687742C1 |
| METHOD OF STREPTOMYCIN DETECTION BY MEANS OF PIEZOELECTRIC IMMUNOSENSOR | 2009 |
|
RU2419797C1 |
| METHOD OF DETERMINING CHOLOROACETENILIDE HYBRIDS (ACETOCHLORINE, BUTACHLOR, ALACHLOR) USING PIEZO-QUARTZ IMMUNOSENSOR | 2007 |
|
RU2326384C1 |
| METHOD OF DETECTING CHLORAMPHENICOL USING PIEZOQUARTZ IMMUNOSENSOR | 2011 |
|
RU2497123C2 |
| METHOD FOR SELECTIVE ASSAY OF NONYLPHENOL IN SOLUTION BY USING PIEZOELECTRIC CRYSTAL IMMUNOSENSOR | 2005 |
|
RU2287820C1 |
| DETECTION OF SULFAMETHOXAZOLE USING PIEZOQUARTZ IMMUNOSENSOR | 2004 |
|
RU2271006C1 |
| METHOD FOR DETECTING CONCENTRATION OF ANTIBODIES IN BLOOD SERA TO PATHOGENIC BACTERIA YERSINIA ENTEROCOLITICA OF SEROVARS O:3, O:5 OR O:6.30 AT APPLICATION OF PIEZOGRAVIMETRIC IMMUNOSENSOR | 2005 |
|
RU2288472C1 |
| METHOD OF DETERMINING LEVOFLOXACIN USING VOLTAMMETRIC SENSOR BASED ON FUNCTIONALISED FULLERENE AND REDUCED GRAPHENE OXIDE | 2024 |
|
RU2826166C1 |
| METHOD OF BLOOD PLASMA PROXIMATE ANALYSIS FOR CARDIOMYOGLOBIN BY MEANS OF ELECTROCHEMICAL IMMUNOSENSOR | 2009 |
|
RU2425382C1 |
