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(19)

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2 706 699

(13)

(51)

IPC

G01N33/48(2006-01-01)

(21) (22)

Application

2019122083, 2019-07-10

(24)

Start date

2019-07-10

(22)

Actual filing date

2019-07-10

(45)

Published

2019-11-20

(72)

Inventor

Karev Vadim EvgenevichKarabak Irina AleksandrovnaLobzin Yurij Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Klinicheskij Tsentr Infektsionnykh Boleznej Federalnogo Mediko-Biologicheskogo Agentstva"

METHOD FOR PREDICTION OF UNFAVORABLE LIVER FIBROSIS IN CHRONIC HEPATITIS C Russian patent published in 2019 - IPC G01N33/48

Abstract RU 2706699 C1

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely to a method for prediction of unfavorable liver fibrosis in chronic hepatitis C. A method for prediction of unfavorable liver fibrosis in chronic hepatitis C by measuring the intensity of cell-mediated immune parenchyma damage, wherein immunohistomorphometric method involves quantitative determination of absolute CD8-positive lymphocyte content in 1 mm² heparin liver parenchyma section and with more than 200 CD8-positive lymphocytes in 1 mm² liver parenchyma and infection with hepatitis C virus 3 genotype, unfavorable hepatic fibrosis in chronic hepatitis C is predicted.

EFFECT: disclosed method provides higher prediction accuracy of unfavorable liver fibrosis in chronic hepatitis C.

1 cl, 2 dwg, 6 tbl, 2 ex

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RU 2 706 699 C1

Authors

Karev Vadim Evgenevich

Karabak Irina Aleksandrovna

Lobzin Yurij Vladimirovich

Dates

2019-11-20—Published

2019-07-10—Filed