FIELD: immunology.
SUBSTANCE: disclosed is a CD19-specific chimeric antigen receptor. Also, a polynucleotide, an expression vector created by genetic engineering of T-lymphocytes are considered. What is also described is a method for creating T-lymphocyte, methods of treating B-cell lymphoma or leukemia.
EFFECT: present invention can find further application in therapy of B-cell lymphoma and leukemia.
26 cl, 6 dwg, 1 tbl, 3 ex
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Authors
Dates
2020-07-21—Published
2014-05-12—Filed