FIELD: biotechnology.
SUBSTANCE: proposed is a heterologous DNA intended to be introduced into the genome of the virus of the “wild” strain of Herpesvirus saimiri, including genetic sequences encoding paired chimeric receptors against CD44 and CD133 tumour antigens, flanked by sections of 300-900 pairs of nucleotide bases homologous to the section of the genome of Herpesvirus saimiri whereto the target fragment is integrated by homologous recombination. Also proposed is a recombinant strain of Herpesvirus saimiri containing a sequence of said DNA in the genome, intended for rapid production of proliferating populations of autologous T lymphocytes expressing paired chimeric antigenic receptors against CD44 and CD133 antigens.
EFFECT: inventions can be used for the purpose of research and diagnostics in order to effectively produce genetically modified immortalised primary T lymphocytes for treating malignant neoplasms, in particular, glioblastomas.
5 cl, 5 dwg
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|
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| SYSTEM FOR STABLE EXPRESSION OF TUMOR-ASSOCIATED ANTIGENS BASED ON LENTIVIRAL VECTOR | 2018 |
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| VIRUS-LIKE CHIMERIC PARTICLES FOR INDUCTION OF SPECIFIC IMMUNITY AGAINST SEVERE ACUTE RESPIRATORY SYNDROME VIRUS SARS-COV-2 CONTAINING CORONAVIRUS AND ROTAVIRUS PROTEINS | 2022 |
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| SYSTEMS FOR EXPRESSION OF NEWCASTLE DISEASE VIRUS RECOMBINANT RNA AND VACCINES | 1999 |
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| IMMUNE CELLS DEFECTIVE BY Suv39h1 | 2018 |
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| ARTIFICIAL ECTOS_SC2 GENE ENCODING AN ECTODOMAIN OF THE SARS-COV-2 CORONAVIRUS S GLYCOPROTEIN WITH A C-TERMINAL TRIMERIZATION DOMAIN, A RECOMBINANT PLASMID PSTEM-RVSV-ECTOS_SC2, WHICH PROVIDES EXPRESSION OF THE ARTIFICIAL GENE, AND A RECOMBINANT STRAIN OF VESICULAR STOMATITIS VIRUS RVSV-ECTOS_SC2, USED TO CREATE A VACCINE AGAINST SARS-COV-2 CORONAVIRUS | 2020 |
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RU2733834C1 |
