BIOCOMPATIBLE BIODEGRADABLE OSTEOCONDUCTIVE POLYMER COMPOSITE MATERIAL FOR BONE TISSUE REGENERATION Russian patent published in 2019 - IPC A61F2/28 A61L27/40 A61L27/58 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of high-molecular weight compounds, specifically to biocompatible biodegradable osteoconductive composite materials based on polyesters and chemically modified nanocellulose. Composite material for bone tissue regeneration is characterized by the fact that it consists of a polyester matrix of an aliphatic hydroxyacid selected from: poly-D,L-lactide, poly-L-lactide, poly-ɛ-caprolactone, polypentadecalactone, polyglycolide, polyhydroxybutyrate, a copolymer of said polyesters; and filler in amount of 1–20 wt%, which is nanocellulose with hydrodynamic particle diameter of 100–600 nm, modified with peptide GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) and at least one anionic poly(amino acid) selected from poly(glutamic acid), poly(aspartic acid), a copolymer of glutamic and aspartic acids, where material is made in form of film or 3D-item.

EFFECT: invention enables to obtain a composite material having a range of mechanical strength properties which enable to use it as an implant for various bone defects, as well as material is biocompatible, non-toxic, capable of calcium exchange, biodegradable, available due to use of commercial initial substances during its production.

3 cl, 8 dwg, 2 tbl, 15 ex