BIORESORBABLE IMPLANT OF BLOOD VESSELS BASED ON NANOFIBERS Russian patent published in 2023 - IPC A61F2/06 A61L27/26 A61L27/34 A61L27/40 A61L27/50 

FIELD: implants.

SUBSTANCE: invention relates to a bioresorbable tubular blood vessel implant based on poly(L-lactide) and poly(ε-caprolactone), consisting of two layers, characterized by the following: the inner layer of the implant, 50–250 μm thick, consists of poly(L-lactide) nanofibers treated at a temperature in the range T = 70–90°C for 30–120 minutes, the outer layer of the implant, 50–250 μm thick, consists of poly(ε-caprolactone), the elastic modulus E of the implant ranges from 10 to 70 MPa, the external diameter of the implant is 1.0–10.0 mm, the internal diameter is 0.5–9.5 mm.

EFFECT: invention provides 1) bioresorbability; 2) effective adhesion and proliferation of endothelial cells, connective and muscle tissues, as well as vascularization and innervation of the walls of the blood vessel; 3) the rate of resorption, which does not exceed the rate of formation of native tissue; 4) tensile strength valuesσ = 1.2 MPa and relative elongationε = 120–150% of the implant, which allows it to be manipulated in both dry and wet conditions; 5) elastic characteristics of the implant, elastic modulus E from 10 to 70 MPa, which make it possible to withstand dynamic cyclic loads acting on the vessel throughout the entire period of reconstruction.

1 cl, 7 ex, 7 dwg, 1 tbl