BIOCOMPATIBLE BIODEGRADABLE SCAFFOLD BASED ON POLYMER COMPOSITE CONTAINING HYDROXYAPATITE NANOPARTICLES Russian patent published in 2021 - IPC C12M3/00 

FIELD: biotechnology.

SUBSTANCE: present invention relates to the field of cellular biology and biotechnology and constitutes a biocompatible and biodegradable scaffold for temporary void filling and tissue regeneration. The described scaffold comprises a copolymer of polylactic and polyglycolic acids or polycaprolactone (PCL) or a mixture thereof in a 1:1 ratio, an alginate crosslinked with calcium ions, and rod-like hydroxyapatite nanoparticles with a length of 150 to 180 nm in a ratio (0.01 g):(0.18 g):(0.05÷0.15 g). The scaffold is porous and has pores lying in two ranges simultaneously: large pores have sizes from 80 to 120 mcm; small pores have sizes in a range of 1 to 10 mcm. The biocompatible and biodegradable scaffold according to the present invention exhibits mechanical stability, as well as absence of cytotoxicity and acute toxicity.

EFFECT: due to the expanded spectrum of used polymers the present invention allows adjusting the mechanical properties of scaffolds and the rate of biodegradation thereof.

1 cl, 1 dwg, 3 tbl, 1 ex