METHOD OF PRODUCING GELS FOR MEDICAL PURPOSES BASED ON L-CYSTEINE, SILVER NITRATE AND POLYVINYL ALCOHOL Russian patent published in 2019 - IPC A61K47/00 A61K9/00 A61K33/38 A61K31/198 

FIELD: medicine.

SUBSTANCE: invention relates to production of gels based on L-cysteine, silver nitrate and polyvinyl alcohol. Method involves mixing an aqueous solution of L-cysteine with an aqueous solution of silver nitrate so that the concentration of L-cysteine in the mixture is from 1.5 to 4.5 mM, and the ratio of molar concentrations of silver nitrate to L-cysteine in the mixture is in range of 1.25 to 1.30, where further mixture is left in the dark place at temperature of 18–28 ^oC for 4–12 hours to form an L-cysteine-silver solution, then successively mixing L-cysteine-silver solution with aqueous solution of polyvinyl alcohol, so that its concentration in the mixture is within 1.0 to 2.0 wt%, and aqueous solution of sulphate with cation from series Na⁺, K⁺, Mg²⁺, Zn²⁺, Ni²⁺, Co²⁺ at concentration of sulphate in mixture within range of 0.075–0.750 mM, after a certain time, depending on concentration of sulphate and type of cation, system changes from liquid state to gel.

EFFECT: invention enables to obtain gels based on L-cysteine, silver nitrate and polyvinyl alcohol, suitable for use as a matrix for encapsulating drug preparations.

1 cl, 3 dwg, 1 ex