FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology, specifically to a composition for inducing stem cell differentiation into adipocytes. Composition for inducing stem cell differentiation into adipocytes for regenerating fatty tissues comprises as an ingredient, exosomes, obtained from adipose tissue-derived stem cells and differentiated into adipocytes, where the exosomes are characterized by that they contain macrophage colony-stimulating factor (MCSF), tumour necrosis factor-α (TNF-α), leptin, insulin, angiopoietin-1 (ANGPT1) and adiponectin with molecular weight 30 kDa (Acrp30). Group of inventions also relates to injection form of preparation containing said composition.
EFFECT: using the given group of inventions enables using the given composition as agents inducing stem cell differentiation, injection forms of tissue regeneration products by exosomes expression of bioactive factors effecting differentiation into adipocytes.
6 cl, 20 dwg, 5 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION INCLUDING EXOSOME OBTAINED FROM STEM CELLS FOR INDUCTION OF ADIPOGENIC DIFFERENTIATION, REGENERATION OF FAT TISSUE, SKIN WHITENING OR CORRECTION OF WRINKLES | 2021 |
|
RU2759508C1 |
| COMPOSITION INCLUDING EXOSOME PRODUCED FROM STEM CELLS FOR INDUCING ADIPOGENOUS DIFFERENTIATION, REGENERATION OF FATTY TISSUE, SKIN WHITENING OR WRINKLE CORRECTION | 2015 |
|
RU2750695C2 |
| METHOD OF OBTAINING EXOSOMES ORIGINING FROM MESENCHYMAL STEM CELLS AND A CULTURAL SOLUTION PRODUCED FROM THEM | 2020 |
|
RU2799432C1 |
| METHOD OF PRODUCING AND CONCENTRATING microRNA-CONTAINING EXOSOMES OF MULTIPOTENT MESENCHYMAL STROMAL CELLS FOR USE IN COSMETIC AND MEDICINAL AGENTS FOR STIMULATING REGENERATIVE PROCESSES AND SLOWING DOWN AGING PROCESSES | 2018 |
|
RU2710368C2 |
| STEM CELLS AND MATRICES OBTAINED FROM ADIPOSE TISSUE | 2000 |
|
RU2306335C2 |
| METHOD FOR ISOLATION OF PLURIPOTENT STEM CELLS FROM UMBILICAL BLOOD EXPRESSING ZNF281 | 2010 |
|
RU2511417C2 |
| BIOMATERIAL BASED ON CELL-FREE MATRIX PRODUCED BY HUMAN MESENCHYMAL STROMAL CELLS, METHOD FOR PREPARING THEREOF AND METHOD OF USING THEREOF TO STIMULATE REGENERATIVE PROCESSES | 2018 |
|
RU2718907C1 |
| COMPOSITION FOR CELL-REPLACEMENT THERAPY OF SOFT TISSUE DEFECTS | 2013 |
|
RU2522816C1 |
| METHOD FOR PRODUCING REGENERATIVE VETERINARY PREPARATION BASED ON EXTRACT OF MESENCHIMAL STEM CELLS AND CONDITIONED MEDIUM | 2016 |
|
RU2662172C2 |
| DRUG FOR TREATMENT OF TISSUE FIBROSIS BASED ON COMPONENTS OF SECRETOME OF MESENCHYMAL STROMAL CELLS, METHOD FOR OBTAINING AND APPLYING REMEDY | 2020 |
|
RU2766707C1 |
