FIELD: chemistry.
SUBSTANCE: invention relates to an agent possessing cytotoxic activity of general formula (1), in which R is selected from the following group of 1-benzylpyrrolidin-3-yl; 2-methoxycarbonyl-5-phenylpyrrolidin-4-yl; 2-methoxycarbonyl-5-(2-(trifluoromethyl)phenyl)pyrrolidin-4-yl; 2-methoxycarbonyl-5-(2-bromophenyl)pyrrolidin-4-yl; 1-acryloyl-2-methoxycarbonyl-5-phenylpyrrolidin-4-yl; 1-(5-(methoxycarbonyl)-2-phenylpyrrolidine-3-carbonyl)-2-methoxycarbonyl-5-phenylpyrrolidin-4-yl; 1-(1-acryloyl-5-(methoxycarbonyl)-2-phenylpyrrolidine-3-carbonyl)-2-methoxycarbonyl-5-phenylpyrrolidin-4-yl; vinyl. Invention also relates to methods for preparing the agent.
EFFECT: obtaining novel agents possessing cytotoxic activity in relation to malignant tumor cell lines – cells of human cervical cancer HeLa.
7 cl, 1 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| REGULATORS OF DERIVATIVES OF STEROIDS, METHODS OF THEIR OBTAINING AND USE | 2019 |
|
RU2803499C1 |
| REGULATORS-DERIVATIVES OF STEROIDS, METHODS OF THEIR OBTAINING AND THEIR USE | 2019 |
|
RU2797408C2 |
| NEW CRYSTAL FORM OF VASCULAR PERMEABILITY BLOCKER COMPOUND | 2020 |
|
RU2809162C2 |
| COMPOUND, METHODS FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION, COMPOUNDS | 2001 |
|
RU2277100C2 |
| SHIP1 MODULATORS AND METHODS RELATED THERETO | 2014 |
|
RU2679805C2 |
| 4-PREGENEN-11Β-17-21-TRIOL-3,20-DIONE DERIVATIVES FOR TREATING EYE DISEASES | 2012 |
|
RU2688159C2 |
| PHARMACEUTICAL COMPOSITIONS AND METHODS FOR APPLICATION OF 4-PREGNEN-11β-17-21-TRIOL-3,20-DIONE DERIVATIVES | 2012 |
|
RU2683775C2 |
| STEROIDS THAT RELEASE NITROGEN OXIDE | 2008 |
|
RU2442790C2 |
| CHEMICAL COMPOUNDS AND USE THEREOF TO IMPROVE QUALITY OF MUSCLES | 2015 |
|
RU2724329C2 |
| MACROHETEROCYCLIC NUCLEOSIDE DERIVATIVES AND ANALOGUES THEREOF, PRODUCTION AND USE | 2017 |
|
RU2731385C1 |
