FIELD: chemistry.
SUBSTANCE: invention relates to an agent having selective cytoprotective, anti-inflammatory and immunomodulatory activities, of general formula:
where R is selected from the following group: tert-butoxycarbonyl, H, as well as to a method for production thereof, where R corresponds to tert-butoxycarbonyl, in which DHEA is esterified with S-benzyl-N-(tert-butoxycarbonyl)-L-cysteine in the presence of tertiary amines and condensing reagents, and to a method for production thereof, where R corresponds to H, in which reaction of (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16, 17-tetradecahydro-1H-cyclopenta-[a]phenanthren-3-yl S-benzyl-N-(tert-butoxycarbonyl)-L-cysteinate with trifluoroacetic acid is performed to form trifluoroacetic salt (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl S-benzyl-L-cysteinate.
EFFECT: obtaining novel compounds which have selective cytoprotective, anti-inflammatory and immunomodulatory activities, which enables their use in protection against electromagnetic radiation and in combating inflammatory diseases.
5 cl, 5 dwg, 6 ex
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