FIELD: biotechnology.
SUBSTANCE: recombinant oncolytic adeno virus is described, containing: a gene encoding interleukin 12 (IL-12); a gene encoding shRNA suppressing the expression of a vessel endothelium growth factor (VEGF). An anticancer composition containing the specified tumor-specific oncolytic adeno virus is also presented. Recombinant adeno virus, according to the present invention, shows an excellent anticancer effect due to enhancing immune functions.
EFFECT: present invention can be used as a key method in the field of cancer treatment.
10 cl, 23 dwg, 1 ex
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