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(19)

RU

(11)

2 777 523

(13)

C2

(51)

IPC

C12N7/00(2006-01-01)

C12N15/113(2010-01-01)

C07K14/64(2006-01-01)

C07K14/54(2006-01-01)

A61K38/19(2006-01-01)

(21) (22)

Application

2020143572, 2018-02-28

(24)

Start date

2018-02-28

(22)

Actual filing date

2018-02-28

(45)

Published

2022-08-05

(72)

Inventor

Yun, Chae OkAhn, Hyo Min

(73)

Holder

Genemedicine Co., Ltd.

ANTICANCER COMPOSITION CONTAINING TUMOR-SPECIFIC ONCOLYTIC ADENO VIRUS AND INHIBITOR OF CONTROL POINT OF IMMUNE RESPONSE Russian patent published in 2022 - IPC C12N7/00 C12N15/113 C07K14/64 C07K14/54 A61K38/19 

Abstract RU 2777523 C2

FIELD: biotechnology.

SUBSTANCE: recombinant oncolytic adeno virus is described, containing: a gene encoding interleukin 12 (IL-12); a gene encoding shRNA suppressing the expression of a vessel endothelium growth factor (VEGF). An anticancer composition containing the specified tumor-specific oncolytic adeno virus is also presented. Recombinant adeno virus, according to the present invention, shows an excellent anticancer effect due to enhancing immune functions.

EFFECT: present invention can be used as a key method in the field of cancer treatment.

10 cl, 23 dwg, 1 ex

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RU 2 777 523 C2

Authors

Yun, Chae Ok

Ahn, Hyo Min

Dates

2022-08-05—Published

2018-02-28—Filed

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