FIELD: biotechnology.
SUBSTANCE: means which is a chromenone derivative: 
I, where n = 1 or 2 or 
II, developing the ability to inhibit the human tyrosyl-DNA phosphodiesterase 1 enzyme is proposed.
EFFECT: it expands the range of means for human tyrosyl-DNA-phosphodiesterase 1 enzyme inhibitors and can be used for development of anticancer drugs.
1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT FOR INHIBITING HUMAN ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON PHENYLCOUMARINES, SENSITIZING TUMORS TO ANTITUMOUR AGENTS | 2019 |
|
RU2724878C1 |
| ADAMANTYL-CONTAINING DERIVATIVES OF 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE HAVING MONOTERPENOID FRAGMENTS USED AS INHIBITORS OF THE ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 | 2020 |
|
RU2761880C1 |
| HYDRAZINE THIAZOLE DERIVATIVES OF USNIC ACID WITH INHIBITORY ACTION TOWARDS HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2015 |
|
RU2612256C1 |
| 2-ACETYL-6-(2-(2-(4-BROMBENZYLIDENE)HYDRAZINYL)THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIOBENZO[B,D]FURAN-1(9BH)-OH, WITH INHIBITING ACTION ON HUMEN TYROSYL-DNA-PHOSPHODIESTERASE 1 | 2016 |
|
RU2627764C1 |
| AGENTS FOR INHIBITING ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON BILE ACIDS | 2018 |
|
RU2689335C1 |
| DERIVATIVES OF 7-HYDROXYCOUMARIN CONTAINING MONOTERPENOID RESIDUES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS (RSV) REPRODUCTION | 2022 |
|
RU2787352C1 |
| AGENT FOR INHIBITING HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME | 2014 |
|
RU2581060C1 |
| AMIDES WHICH COMBINE ADAMANTANE AND MONOTERPENE FRAGMENTS USED AS ORTHOPOXVIRUS INHIBITORS | 2019 |
|
RU2712135C1 |
| 1,1'-(HEXANE-1,6-DIYL)BIS(3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTAREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES TEMOZOLOMIDE ACTIVITY ON GLIOBLASTOMA CELLS | 2019 |
|
RU2724882C1 |
| AGENT FOR INHIBITING THE HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME BASED ON PENTAFURANOSYL NUCLEOSIDE DERIVATIVES | 2019 |
|
RU2748103C1 |
