FIELD: molecular biology; biochemistry.
SUBSTANCE: invention relates to molecular biology, biochemistry and biotechnology, specifically to adamantyl-monoterpene hybrids articulated through 1,3,4-thiadiazole-2-amine and 1H-1,2,4-triazole-3-thiol fragments. The use of adamantyl-containing derivatives of 1,2,4-triazole and 1,3,4-thiadiazole with monoterpenoid fragments as inhibitors of the human tyrosyl-DNA phosphodiesterase 1 enzyme is proposed.
EFFECT: invention expands the arsenal of inhibitors of this enzyme and can be used to develop drugs applicable in antitumor therapy.
1 cl, 1 tbl, 8 ex, 6 dwg
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|
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| CHIRAL S-MONO-PERPENYL-CYSTEINES | 2018 |
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| AGENTS FOR INHIBITING ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON BILE ACIDS | 2018 |
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| METHOD OF OBTAINING CHIRAL S-MONOTHERPENALCISTINES | 2018 |
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|
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| 1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS | 2019 |
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| 5-AMINO-3-(2-AMINOPROPYL)-[1,2,4]THIADIAZOLES | 2011 |
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