FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanic acid (free form of atorvastatin) designated as forms A and B. These forms are characterized by powdery roentgenogram and NMR spectra of solid bodies. Also, invention elates to pharmaceutical compositions based on these forms and to a method for treatment of hyperlipidemia and hypercholesterolemia, osteoporosis, prostate benign hyperplasia and Alzheimer's disease.
EFFECT: valuable medicinal properties of forms and pharmaceutical compositions.
14 cl, 6 tbl, 4 dwg, 1 ex
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