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2 770 091

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(51)

IPC

C07C235/78(2006-01-01)

A61K31/122(2006-01-01)

A61P25/08(2006-01-01)

A61P25/28(2006-01-01)

A61P25/16(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2017124714, 2015-12-16

(24)

Start date

2015-12-16

(22)

Actual filing date

2015-12-16

(45)

Published

2022-04-14

(72)

Inventor

Mollard PolKornel Kristofer R.Vesson Kiron E.Dzhannusis PiterSachit ShazadMirmekhrabi Makhmud

(73)

Holder

Pitisi Terapyutiks, Ink.

POLYMORPHOUS AND AMORPHOUS FORMS OF (R)-2-HYDROXY-2-METHYL-4-(2,4,5-TRIMETHYL-3,6-DIOXOCYCLOHEXA-1,4-DIENYL)BUTANAMIDE Russian patent published in 2022 - IPC C07C235/78 A61K31/122 A61P25/08 A61P25/28 A61P25/16 A61P35/00

Abstract RU 2770091 C2

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to a method of producing polymorphic form I of anhydrous (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide, having an X-ray powder diffraction pattern, containing characteristic peaks at the following angle values: 12.06, 15.33, 17.03 and 17.26, where said values can vary by ±0.2, wherein the method includes the following steps: (a) contacting (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide with a liquid which is isopropanol or mixture of 98 % isopropanol/2 % water (v/v); and (b) removing liquid.

EFFECT: polymorphic form I of anhydrous (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide, having high stability, solubility and non-hygroscopicity.

8 cl, 45 dwg, 20 tbl, 16 ex

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RU 2 770 091 C2

Authors

Mollard Pol

Kornel Kristofer R.

Vesson Kiron E.

Dzhannusis Piter

Sachit Shazad

Mirmekhrabi Makhmud

Dates

2022-04-14—Published

2015-12-16—Filed