FIELD: medicine; biotechnology.
SUBSTANCE: invention refers to biotechnology and medicine, particularly to a technology of conjugates of an antibody with a drug. Disclosed is a compound of chemical formula 1: 
, including a self-splitting group, an antibody having substrate-specificity with respect to the target, and a drug. Linker L is a linker linking A and W of the self-splitting group by covalent bonds and includes at least one link which is an isoprenyl derivative: 
, which is recognized by isoprenoid transferase.
EFFECT: disclosed compounds have high plasma stability and enable the drug to be easily released in the target cells for drug exposure.
22 cl, 22 dwg, 6 tbl, 20 ex
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