FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a Fc-binding polypeptide with improved alkaline stability, comprising a mutant of a Fc-binding domain of protein A Staphylococcus (SpA), where the mutant has a sequence selected from a group consisting of SEQ ID NO: 9–17.
EFFECT: said Fc-binding polypeptide can be used in a separating matrix construct for immunoglobulin recovery resistant to alkaline flushing liquid.
19 cl, 1 dwg, 3 tbl, 3 ex
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