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(19)

(11)

2 713 333

(13)

(51)

IPC

C12N5/783(2010-01-01)

C12N7/00(2006-01-01)

C12R1/93(2006-01-01)

(21) (22)

Application

2016103614, 2014-07-14

(24)

Start date

2014-07-14

(22)

Actual filing date

2014-07-14

(45)

Published

2020-02-04

(72)

Inventor

Khinrichs Kristian S.Rozenberg Stiven A.

(73)

Holder

The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

METHODS OF PREPARING ANTI-HUMAN PAPILLOMAVIRUS ANTIGEN T CELLS Russian patent published in 2020 - IPC C12N5/783 C12N7/00 C12R1/93

Abstract RU 2713333 C2

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. There are presented methods for obtaining a human papillomavirus (HPV) specific T cell population comprising separating an HPV-positive tumor of the head and neck into multiple fragments; culturing multiple fragments separately; obtaining T-cells from cultured multiple fragments; testing separately T-cells from multiple fragments for specific HPV recognition; selection of T-cells, which demonstrate specific HPV recognition, and increased number of selected T-cells for obtaining a population of HPV-specific T-cells.

EFFECT: present invention can find further application in adoptive cell therapy.

13 cl, 22 dwg, 8 tbl, 12 ex

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RU 2 713 333 C2

Authors

Khinrichs Kristian S.

Rozenberg Stiven A.

Dates

2020-02-04—Published

2014-07-14—Filed