FIELD: biotechnology.
SUBSTANCE: method of treating or preventing HPV+ cancer in a mammal is described. The method includes the steps of dividing an HPV+ tumor sample into multiple fragments, culturing them in the presence of at least one cytokine, obtaining T-cells from the cultured fragments, testing individual T-cells for HPV-specific recognition, selecting HPV-specific T-cells, and increasing the number of selected T-cells to obtain an increased population of HPV-specific T-cells, administering the population of HPV-specific T-cells to the mammal in an effective amount. HPV+ cancer is either head and neck cancer or cervical cancer.
EFFECT: invention expands the arsenal of methods for treating or preventing HPV+ cancer in mammals.
12 cl, 22 dwg, 8 tbl, 11 ex
