FIELD: cell biology.
SUBSTANCE: method for obtaining a population of cells enriched in tumor-reactive T cells, comprising: (a) obtaining a total population of T cells from a tumor sample; (b) specific selecting of CD8 + T cells expressing one or more of TIM-3, LAG-3, 4-1BB and PD-1 from the general population; and (c) separating the cells selected in step (b) from the unselected cells to obtain a cell population enriched in tumor-reactive T cells.
EFFECT: obtaining a population of cells enriched with tumor-reactive T cells.
9 cl, 8 dwg, 2 tbl, 6 ex
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