METHOD AND DEVICE FOR LOCAL MECHANICAL ACTION ON BIOCHEMICAL SYSTEMS CONTAINING MAGNETIC NANOPARTICLES Russian patent published in 2020 - IPC A61N2/00 B82B1/00 B82Y5/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to biomedicine and biomedical engineering and can be used in both research and applied problems of biomedicine: development of new technologies in targeted drug delivery, investigation of nanomechanical effect on macromolecular and cellular structures to control their functioning, oncotherapy, and so forth. Method of local exposure to alternating magnetic field on biochemical systems with pre-introduced functionalized magnetic nanoparticles consists in controlling magnetic nanoparticles using a combination of constant gradient magnetic field with intensity H_g and alternating magnetic field with amplitude H_a, according to the invention, to localize the action in the region of radius R*, periodic reorientation of magnetic nanoparticles in a low-frequency alternating magnetic field with amplitude H_a = R* ∙ grad(H_g) and angular frequency less than any (or less) of two values of 1000 s^-1 is performed and ω_c=μμ₀H_a/(6ηV_HD)∙ (where μ - magnetic moment of magnetic nanoparticle, V_HD - its hydrodynamic volume, μ₀ is magnetic permeability of vacuum, η is ambient viscosity). Device for local nanomechanical action on biochemical systems containing magnetic nanoparticles consisting of unit generating gradient magnetic field H_g, coil assembly creating homogeneous magnetic field H_b, which changes the position of the region of action of the variable magnetic field, the coil assembly creating the variable field which controls the movement of the magnetic nanoparticles, and controlled sources of direct and alternating current for supply of corresponding coils. Assembly of coils creating alternating magnetic field generates magnetic field with angular frequency less than any of two values - 1000 s^-1 and ω_c=μμ₀H_a/(6ηV_HD) (where μ - magnetic moment of magnetic nanoparticle, V_HD - its hydrodynamic volume, μ₀ is magnetic permeability of vacuum, η - viscosity of environment), providing periodic mechanical reorientation of magnetic nanoparticles.

EFFECT: method and apparatus provide nanomechanical action on single molecules and molecular structures or cells in selected limited biochemical system with magnetic nanoparticles introduced therein by periodic reorientation of magnetic nanoparticles into low-frequency alternating magnetic field.

9 cl, 4 dwg