CONJUGATE BASED ON MAGNETIC NANOPARTICLES FOR THERAPY OF SOLID TUMORS AND METHOD FOR PREPARATION THEREOF Russian patent published in 2024 - IPC A61K47/02 A61K47/10 A61P35/00 B82B3/00 B82Y5/00 

FIELD: biotechnology; medicine.

SUBSTANCE: invention relates to biotechnology and medicine, specifically to a nanoconjugate for therapy of malignant solid tumours and a method for obtaining thereof. Nanoconjugate includes nanosized particle of iron oxide and anticancer preparation doxorubicin, wherein nanosized magnetic particle of iron oxide Fe_nFe_3-nO₄, where 0 ≤ n ≤ 1 is coated with a layer of SiO₂functionalised with 3-aminopropylsilane, covalently bonded to SiO₂ and molecules of bifunctional polyethylene glycol with molar weight from 1,000 to 10,000 Da with terminal carboxyl groups. Method of producing the nanoconjugate consists in depositing iron oxide on a nanosized magnetic particle Fe_nFe_3-nO₄, where 0 ≤ n ≤ 1, layer of SiO₂ using tetramethylorthosilicate (TMOS) or tetraethoxysilane (TEOS), its modification with (3-aminopropyl) trimethoxysilane (APTMS) or (3-aminopropyl) triethoxysilane (APTES), subsequent covalent bonding with molecules of bifunctional polyethylene glycol with a molar weight of 1,000 to 10,000 Da with terminal carboxyl groups due to formation of an amide bond and fixation on the surface of the anticancer preparation doxorubicin. There is also a possibility of monitoring its distribution in the tumour by MRI.

EFFECT: disclosed nanoconjugate enables therapy of malignant solid tumours by combining the effect of local hyperthermia (when using an alternating magnetic field) and chemotherapy (due to the presence of an anticancer drug in the nanoconjugate).

2 cl, 9 dwg, 4 tbl, 6 ex