DIAGNOSTIC TECHNIQUE FOR GLIOBLASTOMA MULTIFORME BY MAGNETIC RESONANCE TOMOGRAPHY Russian patent published in 2014 - IPC A61B5/55 B82B1/00 A61K49/16 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to glioblastoma multiforme diagnostic technique by magnetic resonant tomography (MRT). The technique involves magnetic resonant tomography before and after intravenous administration of a contrast agent. The latter is presented by magnetic nanoparticles of ferric oxide stabilised by a biocompatible polymer and conjugated with monoclonal antibodies to the vascular endothelial growth factor. The particles have a hydrodynamic diameter of less than 150 nm. Magnetic resonant tomography is performed in the Susceptibility Weighted Imaging (SWI) mode providing the susceptibility weighted imaging of the examined region. Glioblastoma multiforme is detected by comparison results of the MR images before and after administration of the contrast agent as shown by low-brightness areas on the MR images.

EFFECT: technique provides higher reliability and information value of diagnosing by increasing a contrast value of the areas corresponding to glioblastoma tissues, its vessels and neoangiogenesis centres.

13 cl, 4 ex, 1 tbl, 1 dwg