METHODS AND COMPOSITIONS FOR DESTROYING AGING CELLS AND FOR TREATING DISEASES AND DISORDERS ASSOCIATED WITH AGING Russian patent published in 2020 - IPC A61K31/496 A61P9/10 A61P11/00 A61P19/02 

Abstract RU 2716256 C2

FIELD: medicine.

SUBSTANCE: invention relates to a method of treating osteoarthritis in a subject, comprising administering to a subject a therapeutically effective amount of a low molecular weight cenolytic agent which selectively kills aging cells as compared to age-old cells. Aging cells are identified as p16-positive cells that are not cancer cells. Cenolytic agent is an MDM2 inhibitor and is administered directly into a joint affected by osteoarthritis. Also disclosed is a version of a method of treating osteoarthritis, a method of treating a non-proliferative associated with aging pulmonary disease or disorder in a subject and a method for increasing the stability of the atherosclerotic plaque.

EFFECT: invention enables treatment of diseases by selective killing of aging cells by administering a cenolytic agent.

54 cl, 72 dwg, 32 ex

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RU 2 716 256 C2

Authors

Laberge Remi-Martin

Campisi Judith

Davalos Albert

Demaria Marco

David Nathaniel

Vasserot Alain Philippe

Baker Darren J.

Childs Bennett G.

Kirkland James L.

Tchkonia Tamar

Van Deursen Jan M.A.

Zhu Yi

Elisseeff Jennifer

Kim Chaekyu

Jeon Okhee

Dates

2020-03-11Published

2015-01-28Filed