FIELD: biotechnology.
SUBSTANCE: invention relates to variants of the engineered CRISPR-Cas system containing the Cas9 protein or one or more nucleic acids encoding this Cas9 protein, and the first and second RNA of the CRISPR-Cas system or one or more nucleic acids encoding these first and a second RNA of the CRISPR-Cas system.
EFFECT: invention is effective for modifying a eukaryotic cell.
50 cl, 23 dwg, 5 tbl, 8 ex
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