FIELD: biotechnology.
SUBSTANCE: invention relates to variants of the engineered CRISPR-Cas system containing the Cas9 protein or one or more nucleic acids encoding this Cas9 protein, and the first and second RNA of the CRISPR-Cas system or one or more nucleic acids encoding these first and a second RNA of the CRISPR-Cas system.
EFFECT: invention is effective for modifying a eukaryotic cell.
50 cl, 23 dwg, 5 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPONENTS OF THE CRISPR-CAS SYSTEM, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION | 2013 |
|
RU2796549C2 |
| NEW ENZYMES AND CRISPR SYSTEMS | 2016 |
|
RU2777988C2 |
| DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY | 2013 |
|
RU2721275C2 |
| NEW CRISPR ENZYMES AND SYSTEMS | 2016 |
|
RU2771826C2 |
| RNA-GUIDED TRANSCRIPTION REGULATION | 2014 |
|
RU2756865C2 |
| DNA-CUTTING AGENT BASED ON THE Cas9 PROTEIN FROM THE BACTERIUM CAPNOCYTOPHAGA OCHRACEA | 2021 |
|
RU2778156C1 |
| CRISPR/CAS9 TYPE II GENOME EDITING SYSTEM AND ITS USE | 2022 |
|
RU2794774C1 |
| NOVEL ENZYMES AND CRISPR SYSTEMS | 2016 |
|
RU2737537C2 |
| TOOL FOR CUTTING DOUBLE-STRANDED DNA USING CAS12D PROTEIN FROM KATANOBACTERIA AND HYBRID RNA PRODUCED BY FUSION OF GUIDE CRISPR RNA AND SCOUT RNA | 2020 |
|
RU2771626C1 |
| DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED ACTION AND MODELING OF DISEASES AND DISORDERS OF POSTMITOTIC CELLS | 2014 |
|
RU2725502C2 |
