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(19)

(11)

2 721 275

(13)

(51)

IPC

C12N15/85(2006-01-01)

C12N15/90(2006-01-01)

C12N15/63(2006-01-01)

C12N15/113(2010-01-01)

A61K48/00(2006-01-01)

C12N9/22(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

2015128057, 2013-12-12

(24)

Start date

2013-12-12

(22)

Actual filing date

2013-12-12

(45)

Published

2020-05-18

(72)

Inventor

Chzhan FenKhajdenrajkh MattiasZhan FejSuich Lukash

(73)

Holder

Te Brod Instityut, Ink.Massachusets Instityut Of TeknolodzhiPrezident End Fellouz Of Kharvard Kollidzh

DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY Russian patent published in 2020 - IPC C12N15/85 C12N15/90 C12N15/63 C12N15/113 A61K48/00 C12N9/22 C12N5/10

Abstract RU 2721275 C2

FIELD: biotechnology.

SUBSTANCE: methods are proposed for modifying a eukaryotic organism by manipulating a target sequence in a genome locus of interest by using the CRISPR-Cas system, as well as a method of treating or inhibiting a condition caused by a defect in a target sequence, and a composition containing components of said system.

EFFECT: present invention enables the change of genomic loci of the eukaryotic cell by using Cas9 nuclease fused with one or more nuclear localization sequences (NLS).

21 cl, 73 dwg, 35 tbl, 37 ex

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RU 2 721 275 C2

Authors

Chzhan Fen

Khajdenrajkh Mattias

Zhan Fej

Suich Lukash

Dates

2020-05-18—Published

2013-12-12—Filed