Show metadata Hide metadata

(19)

(11)

2 721 275

(13)

(51)

IPC

C12N15/85(2006-01-01)

C12N15/90(2006-01-01)

C12N15/63(2006-01-01)

C12N15/113(2010-01-01)

A61K48/00(2006-01-01)

C12N9/22(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

2015128057, 2013-12-12

(24)

Start date

2013-12-12

(22)

Actual filing date

2013-12-12

(45)

Published

2020-05-18

(72)

Inventor

Chzhan FenKhajdenrajkh MattiasZhan FejSuich Lukash

(73)

Holder

Te Brod Instityut, Ink.Massachusets Instityut Of TeknolodzhiPrezident End Fellouz Of Kharvard Kollidzh

DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY Russian patent published in 2020 - IPC C12N15/85 C12N15/90 C12N15/63 C12N15/113 A61K48/00 C12N9/22 C12N5/10

Abstract RU 2721275 C2

FIELD: biotechnology.

SUBSTANCE: methods are proposed for modifying a eukaryotic organism by manipulating a target sequence in a genome locus of interest by using the CRISPR-Cas system, as well as a method of treating or inhibiting a condition caused by a defect in a target sequence, and a composition containing components of said system.

EFFECT: present invention enables the change of genomic loci of the eukaryotic cell by using Cas9 nuclease fused with one or more nuclear localization sequences (NLS).

21 cl, 73 dwg, 35 tbl, 37 ex

Similar patents RU2721275C2

Title	Year	Author	Number
SYSTEM DESIGN, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Zhang, Feng Cong, Le Hsu, Patrick Ran, Fei	RU2796017C2
COMPONENTS OF THE CRISPR-CAS SYSTEM, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Zhang, Feng Bikard, David, Olivier Cong, Le Cox, David Benjamin, Turitz Hsu, Patrick Jiang, Wenyan Lin, Shuailiang Marraffini, Luciano Platt, Randall, Jeffrey Ran, Fei Sanjana, Neville, Espi	RU2796549C2
NEW ENZYMES AND CRISPR SYSTEMS	2016	Kunin Yudzhin Chzhan Fen Volf Yurij I. Shmakov Sergej Severinov Konstantin Semenova Ekaterina Minakhin Leonid Makarova Kira S. Konermann Silvana Dzhung Dzhuliya Gutenberg Dzhonatan S. Abudajekh Omar O.	RU2777988C2
RNA-GUIDED TRANSCRIPTION REGULATION	2014	Church, George M. Mali, Prashant G. Esvelt, Kevin M.	RU2756865C2
NEW CRISPR ENZYMES AND SYSTEMS	2016	Severinov Konstantin Chzhan Fen Volf Yurij I. Shmakov Sergej Semenova Ekaterina Minakhin Leonid Makarova Kira S. Kunin Yudzhin Konermann Silvana Dzhung Dzhuliya Gutenberg Dzhonatan S. Abudajekh Omar O. Lander Erik S.	RU2771826C2
DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED ACTION AND MODELING OF DISEASES AND DISORDERS OF POSTMITOTIC CELLS	2014	Chzhan Fen Khajdenrajkh Mattias Suich Lukash	RU2725502C2
DELIVERY, USE AND USE IN THERAPY OF CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETED ACTION ON DISORDERS AND DISEASES USING VIRAL COMPONENTS	2014	Chzhan Fen Tsun Le Zhan Fej Khajdenrajkh Mattias Suich Lukash	RU2716421C2
GENOMIC ENGINEERING	2014	Church, George M. Yang, Luhan Cargol, Marc Guell Yang, Joyce Lichi	RU2764757C2
GENOME ENGINEERING	2021	Church, George M. Yang, Luhan Cargol, Marc Guell Yang, Joyce Lichi	RU2812848C2
CRISPR/CAS9 TYPE II GENOME EDITING SYSTEM AND ITS USE	2022	Tian Rui Huang Long Xie Hongxian	RU2794774C1

RU 2 721 275 C2

Authors

Chzhan Fen

Khajdenrajkh Mattias

Zhan Fej

Suich Lukash

Dates

2020-05-18—Published

2013-12-12—Filed