FIELD: medicine.
SUBSTANCE: group of inventions relates to oncology, and can be used in the treatment of myelofibrosis. According to the invention, the methods comprise administering to a patient a therapeutically effective amount of a serum amyloid P (SAP) agonist, glycosylated human SAP polypeptide comprising an N-linked oligosaccharide chain, wherein the at least one branch of the oligosaccharide chain terminating with a α2,3-linked sialic acid, one or multiple times at initial loading dose during the first week of administration, and then once every 1–4 weeks.
EFFECT: use of inventions allows restoring bone marrow function by decreasing fibrosis in patients.
32 cl, 4 dwg, 4 tbl, 6 ex
| Title |
Year |
Author |
Number |
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|
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|
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|
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|
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2015 |
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- Gill, Saar
- Glass, David
- Johnson, Amy
- June, Carl, H.
- Kenderian, Saad
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|
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