COMPOSITIONS AND METHODS FOR MYELOFIBROSIS TREATMENT Russian patent published in 2017 - IPC A61K31/506 A61K47/38 A61K47/14 A61K9/48 A61J3/07 A61P7/00 A61P35/00 

FIELD: medicine, pharmacy.

SUBSTANCE: capsule containing a mixture of a compound which is N-tert-butyl-3-[(5-methyl-2-{[4- (2-pyrrolidin-1-lethoxi)phenyl]amino} pyrimidin-4-yl)amino]benzenesulphonamide, or a pharmaceutically acceptable salt or hydrate thereof, microcrystalline cellulose and sodium stearyl fumarate. The mixture contains from 10 to 500 mg of the said compound. The weight ratio of the compound to microcrystalline cellulose in the mixture is within the range from 1:1.5 to 1:15. The amount of sodium stearyl fumarate in the mixture is 1% by weight of the capsule contents. A method of capsulesproduction, a method for myelofibrosis treatment and a kit for myelofibrosis treatment are also described. N-tert-butyl-3-[(5-methyl-2-{[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl] amino} pyrimidin-4-yl)amino]benzenesulphonamide medication provided as a capsule shows stability and instant release characteristics.

EFFECT: invention describes a capsule for oral administration for treatment of myelofibrosis.

38 cl, 18 dwg, 25 tbl, 6 ex