FIELD: biotechnology.
SUBSTANCE: invention relates to the methods of increasing the length of the telomere in one or more human cells and/or increasing the stability of the genome of one or more human cells, for example, by bringing one or more human cells into contact with an agent that increases the level of expression of Zscan4 in one or more human cells. The invention also relates to a method for rejuvenating one or more human cells; to a method for rejuvenating tissues or organs and rejuvenating an individual in need thereof, for example, by bringing one or more human cells into contact with an agent that increases the level of Zscan4 expression, or by administering to an individual in need thereof, an agent that increases the level of Zscan4 expression.
EFFECT: using Zscan4 for human cell rejuvenation.
46 cl, 19 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS OF USING ZSCAN4 FOR HUMAN CELL REJUVENATION | 2014 |
|
RU2735141C2 |
| METHOD FOR INCREASING RNA EXPRESSION IN CELL | 2018 |
|
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| NON-HUMAN ANIMALS HAVING HUMANIZED GENE OF DIFFERENTIATION CLUSTER 274 | 2015 |
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| GENETICALLY MODIFIED ANIMALS NOT RELATED TO HUMAN RACE AND THEIR APPLICATION METHODS | 2013 |
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| METHOD FOR PRODUCING HIGH-QUALITY INDUCED PLURIPOTENT STEM CELLS (IPSC) | 2016 |
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| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR USE THEREOF | 2013 |
|
RU2673156C2 |
| 5'-CAP-TRINUCLEOTIDE COMPOUNDS OR 5'-CAP COMPOUNDS WITH LARGE NUMBER OF NUCLEOTIDES AND THEIR USE FOR RNA STABILIZATION, PROTEIN EXPRESSION AND IN THERAPY | 2019 |
|
RU2811940C2 |
| NON-HUMAN GENETICALLY MODIFIED ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2711744C1 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHOD FOR THEIR APPLICATION | 2013 |
|
RU2642319C2 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2799086C2 |
