PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS Russian patent published in 2020 - IPC C07D487/04 A61K31/4985 A61P37/02 A61P29/00 A61P25/28 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to a compound having structure (I), or a pharmaceutically acceptable salt thereof, where A, A' and A'' are independently O, C = O, CR' or NR'', where R' and R'' can independently be H, amino, -NR₇COR₆, -CONR₇R₈, C₁-C₆ alkyl or hydroxy(C₁-C₆ alkyl)-, and R'' can be present or absent and is present where valence rules enable, and where not more than one of A, A' and A'' is O; R₀ and R independently represent H or C₁-C₆ alkyl; R₁ is H; R₂ is selected from a group consisting of H, C₁-C₆ alkyl-, C₁-C₆ alkoxy-, phenyl(C₁-C₆ alkyl)-, pyrazole, -COR₆ and -(CH₂)_n-W, where W is cyano, hydroxy, C₃-C₈ cycloalkyl and -SO₂-R₉, where R₉ is C₁-C₆ alkyl; where each of said alkyl and cycloalkyl can be unsubstituted or substituted with halogen; X is CR₃ or N, where R₃ can be H or C₁-C₆ alkyl; R₄ and R₅ independently represent H, amino, C₁-C₆ alkyl or hydroxy(C₁-C₆ alkyl)-; R₆, R₇ and R₈ each independently represent H, C₁-C₆ alkyl or C₃-C₈ cycloalkyl and n equals 0, 1, 2 or 3.

EFFECT: pyrazolo[1,5-a]pyrazin-4-yl derivatives have inhibitory action on janus kinase (JAK).

24 cl, 2 tbl, 37 ex