METHOD OF PRODUCING A PHARMACEUTICAL AGENT FOR CANCER IMMUNOTHERAPY Russian patent published in 2020 - IPC G16C20/60 C07K16/00 A61K35/17 A61K39/00 C07K16/32 

FIELD: biotechnology.

SUBSTANCE: what is presented is a method for preparing a pharmaceutical agent for cancer immunotherapy. Method involves using osmotic tumor data, for which there is paired normal data, to obtain in silico a plurality of patient- and cancer-specific neoepitope n-measures cancer, selecting in silico n-measures to obtain a subset of sequences of neoepitopes, obtaining a synthetic n-dimensional peptide using information on the sequence of a subset of sequences of neoepitopes, use of synthetic n-dimensional peptide for recovery of recombinant antibody, obtaining information on sequence of complementarity determining region of recombinant antibody, obtaining a synthetic antibody using information on a complementarity determining region of a recombinant antibody and attaching a synthetic antibody to the therapeutic or diagnostic agent to obtain a pharmaceutical agent.

EFFECT: invention provides fast identification of patient-tumor antigens and in a short time obtaining antibodies aimed at such antigens for diagnostic or therapeutic application.

19 cl, 2 dwg, 1 tbl